منابع مشابه
Synaptic Vesicles Caught Kissing Again
In this issue of Neuron, Harata et al. use a novel quenching technique to provide compelling evidence that kiss-and-run is the dominant mode of vesicle fusion at hippocampal synapses and that the prevalence of kiss-and-run can be modulated by stimulus frequency. The increased incidence of kiss-and-run at lower frequencies may ensure that vesicles are available for use during periods of high dem...
متن کاملImaging single synaptic vesicles undergoing repeated fusion events: kissing, running, and kissing again.
At synapses of the mammalian central nervous system, release of neurotransmitter occurs at rates transiently as high as 100 Hz, putting extreme demands on nerve terminals with only tens of functional vesicles at their disposal. Thus, the presynaptic vesicle cycle is particularly critical to maintain neurotransmission. To understand vesicle cycling at the most fundamental level, we studied singl...
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متن کاملSynaptic vesicles
Aside from forming ion channels, what else do claudins do? Claudins and occludin (also a four-pass integral membrane protein) interact laterally in the membrane circumscribing the cell to form a ‘fence’. This barrier prevents the diffusion of extracellularly facing lipids between apical and basolateral plasma membrane domains. The tight junction may also be an important component of several sig...
متن کاملThe Synaptic Vesicle Cycle: Is Kissing Overrated?
In this issue of Neuron, Granseth et al. re-examine the mechanism of endocytosis at hippocampal synapses using a new optical reporter, sypHy. They conclude that only a single slow mode of endocytosis operates at this synapse and that retrieval after physiological stimuli is largely, if not solely, dominated by the clathrin-mediated pathway. These conclusions dispute previous assertions that "ki...
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ژورنال
عنوان ژورنال: Neuron
سال: 2006
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2006.01.003